Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico

Reactive oxygen species, which induce oxidative stress in the body, are one of the risk factors for some cancer types. In Mexico, the types of cancer with the highest mortality are prostate, breast, cervical, lung, and liver. Natural products represent the oldest form of medicinal remedies; for canc...

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Autores principales:	Vidal Gutiérrez, Max, Torres Moreno, Heriberto, Velázquez Contreras, Carlos Arturo, Rascón Valenzuela, Luisa Alondra, Robles Zepeda, Ramón Enrique
Formato:	Online
Lenguaje:	spa
Publicado:	Universidad de Sonora 2020
Acceso en línea:	https://biotecnia.unison.mx/index.php/biotecnia/article/view/1169
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spelling	biotecnia-article-11692022-05-31T17:20:08Z Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico Actividad Antioxidante y Antiproliferativa de Seis Plantas Medicinales del Noroeste de México Vidal Gutiérrez, Max Torres Moreno, Heriberto Velázquez Contreras, Carlos Arturo Rascón Valenzuela, Luisa Alondra Robles Zepeda, Ramón Enrique Antiproliferative Activity Antioxidant Bursera Jacquinia Acacia Actividad antioxidante Actividad antiproliferativa Bursera Jacquinia Acacia Reactive oxygen species, which induce oxidative stress in the body, are one of the risk factors for some cancer types. In Mexico, the types of cancer with the highest mortality are prostate, breast, cervical, lung, and liver. Natural products represent the oldest form of medicinal remedies; for cancer, this source is no exception. In this investigation, we studied the antiproliferative activities, by MTT, and the antioxidant activity, by ABTS and DPPH, in six northwestern Mexico medicinal plants. The Jacquinia macrocarpa ssp. pungens fruit shells showed the best antiproliferative activity with an IC50 of 9.2 μg/mL in A549, followed by Bursera microphylla with IC50 13.8 μg/mL in HeLa. Bursera laxiflora showed the best antioxidant activity of the six plants against ABTS and DPPH radicals, and also presented antiproliferative activity in HeLa. The bark of B. laxiflora contains compounds with antioxidant activities, which are probably also the same that induce antiproliferative activity in cancer cell lines. On the other hand, J. macrocarpa showed no antioxidant activity. However, the three species of plants represent a potential source of molecules with antiproliferative activity. Las especies reactivas de oxígeno, que inducen estrés oxidativo en el organismo, son uno de los factores de riesgo para padecer de algún tipo de cáncer. En México los tipos de cáncer con mayor mortalidad son el de próstata, mama, cervicouterino, pulmón e hígado. Los productos naturales representan la forma más antigua de remedios medicinales, para el cáncer esta fuente no es una excepción. En esta investigación, se estudió la actividad antioxidante por ABTS y DPPH, y la actividad antiproliferativa de seis plantas medicinales del noroeste de México. Las cáscaras del fruto de Jacquinia macrocarpa ssp pungens mostraron la mejor actividad antiproliferativa del estudio con una IC50 de 9.2 mg/mL en A549, seguido por B microphylla con IC50 de 13.8 mg/mL en HeLa. Bursera laxiflora obtuvo la mejor actividad antioxidante de las seis plantas frente a los radicales ABTS y DPPH, así como también presentó actividad antiproliferativa en HeLa. La corteza de B. laxiflora contiene compuestos con actividad antioxidante, que probablemente, también sean los mismos que inducen la actividad antiproliferativa en células cancerosas. Por otro lado, J.  macrocarpa y B. microphylla no presentan actividad antioxidante, sin embargo, las tres especies vegetales representan una fuente potencial de moléculas con actividad antiproliferativa. Universidad de Sonora 2020-09-21 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original peer-reviewed articles Artículos originales evaluados por pares application/pdf text/xml https://biotecnia.unison.mx/index.php/biotecnia/article/view/1169 10.18633/biotecnia.v22i3.1169 Biotecnia; Vol. 22 No. 3 (2020): Septiembre-Diciembre; 40-45 Biotecnia; Vol. 22 Núm. 3 (2020): Septiembre-Diciembre; 40-45 1665-1456 1665-1456 spa https://biotecnia.unison.mx/index.php/biotecnia/article/view/1169/450 https://biotecnia.unison.mx/index.php/biotecnia/article/view/1169/505 Derechos de autor 2020 Biotecnia
institution	Biotecnia
collection	OJS
language	spa
format	Online
author	Vidal Gutiérrez, Max Torres Moreno, Heriberto Velázquez Contreras, Carlos Arturo Rascón Valenzuela, Luisa Alondra Robles Zepeda, Ramón Enrique
spellingShingle	Vidal Gutiérrez, Max Torres Moreno, Heriberto Velázquez Contreras, Carlos Arturo Rascón Valenzuela, Luisa Alondra Robles Zepeda, Ramón Enrique Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico
author_facet	Vidal Gutiérrez, Max Torres Moreno, Heriberto Velázquez Contreras, Carlos Arturo Rascón Valenzuela, Luisa Alondra Robles Zepeda, Ramón Enrique
author_sort	Vidal Gutiérrez, Max
title	Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico
title_short	Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico
title_full	Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico
title_fullStr	Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico
title_full_unstemmed	Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico
title_sort	antioxidant and antiproliferative activity of six medicinal plants from northwestern mexico
description	Reactive oxygen species, which induce oxidative stress in the body, are one of the risk factors for some cancer types. In Mexico, the types of cancer with the highest mortality are prostate, breast, cervical, lung, and liver. Natural products represent the oldest form of medicinal remedies; for cancer, this source is no exception. In this investigation, we studied the antiproliferative activities, by MTT, and the antioxidant activity, by ABTS and DPPH, in six northwestern Mexico medicinal plants. The Jacquinia macrocarpa ssp. pungens fruit shells showed the best antiproliferative activity with an IC50 of 9.2 μg/mL in A549, followed by Bursera microphylla with IC50 13.8 μg/mL in HeLa. Bursera laxiflora showed the best antioxidant activity of the six plants against ABTS and DPPH radicals, and also presented antiproliferative activity in HeLa. The bark of B. laxiflora contains compounds with antioxidant activities, which are probably also the same that induce antiproliferative activity in cancer cell lines. On the other hand, J. macrocarpa showed no antioxidant activity. However, the three species of plants represent a potential source of molecules with antiproliferative activity.
publisher	Universidad de Sonora
publishDate	2020
url	https://biotecnia.unison.mx/index.php/biotecnia/article/view/1169
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Antioxidant and antiproliferative activity of six medicinal plants from northwestern Mexico

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