Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth
The fruit of Randia monantha is traditionally and empirically used in the preparation of a beverage as antivenom and for the treatment of various diseases, but to date there is little scientific evidence regarding its antimicrobiological properties and toxicity. The objective of this study was to ev...
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Universidad de Sonora
2022
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biotecnia-article-15162022-05-31T17:40:22Z Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth Antibacterial activity and acute toxicity study of standardized aqueous extract of Randia monantha Benth fruit Juárez-Trujillo, Naida Tapia-Hernández, Fredy Erubiel Alvarado-Olivarez, Mayvi Beristain-Guevara, César Ignacio Pascual-Pineda, Luz Alicia Jiménez Fernández, Maribel Acute toxicity antimicrobian properties crucetillo Randia monantha rats Toxicidad aguda propiedades antimicrobianas crucetillo Randia monantha ratas The fruit of Randia monantha is traditionally and empirically used in the preparation of a beverage as antivenom and for the treatment of various diseases, but to date there is little scientific evidence regarding its antimicrobiological properties and toxicity. The objective of this study was to evaluar the effect of the administration of the aqueous extract of the Randia monantha pulp on acute toxicity in male Wistar rats and evaluate antimicrobial activity at different concentrations against pathogenic bacteria. The results of acute oral toxicity revealed no deaths in doses up to 5000 mg / kg body weight. The experimental animals showed no significant changes in the weight and behavior parameters evaluated with respect to the control treatment. Rats did not show significant changes in the hematological parameters, but dosis of 5000 mg/kg body weight rats exhibited the appearance of yellow spots on kidney. The aqueous extract did not show antimicrobial activity against test pathogenic bacteria. These results suggest that the aqueous extract of the Randia monantha fruit can be used with some degree of safety by oral administration but should not be taken in high doses. El fruto de Randia monantha se utiliza tradicional y empíricamente en la preparación de una bebida como antiveneno y para el tratamiento de diversas enfermedades, pero hasta la fecha existe poca evidencia científica sobre sus propiedades antimicrobiológicas y toxicidad. El objetivo de este estudio fue evaluar el efecto de la administración del extracto acuoso de pulpa de Randia monantha sobre la toxicidad aguda en ratas Wistar macho y evaluar la actividad antimicrobiana a diferentes concentraciones frente a bacterias patógenas. Los resultados de la toxicidad oral aguda no revelaron muertes en dosis de hasta 5000 mg / kg de peso corporal. Los animales de experimentación no mostraron cambios significativos en los parámetros de peso y comportamiento evaluados con respecto al tratamiento control. Las ratas no mostraron cambios significativos en los parámetros hematológicos, pero las ratas con dosis de 5000 mg / kg de peso corporal mostraron la aparición de manchas amarillas en el riñón. El extracto acuoso no mostró actividad antimicrobiana contra las bacterias patógenas de prueba. Estos resultados sugieren que el extracto acuoso de la fruta Randia monantha puede usarse con cierto grado de seguridad por administración oral, pero no debe tomarse en dosis altas. Universidad de Sonora 2022-02-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original peer-reviewed articles Artículos originales evaluados por pares application/pdf text/xml https://biotecnia.unison.mx/index.php/biotecnia/article/view/1516 10.18633/biotecnia.v24i1.1516 Biotecnia; Vol. 24 No. 1 (2022): Enero-Abril; 38-45 Biotecnia; Vol. 24 Núm. 1 (2022): Enero-Abril; 38-45 1665-1456 1665-1456 eng https://biotecnia.unison.mx/index.php/biotecnia/article/view/1516/630 https://biotecnia.unison.mx/index.php/biotecnia/article/view/1516/666 Derechos de autor 2022 https://creativecommons.org/licenses/by-nc-sa/4.0 |
| institution |
Biotecnia |
| collection |
OJS |
| language |
eng |
| format |
Online |
| author |
Juárez-Trujillo, Naida Tapia-Hernández, Fredy Erubiel Alvarado-Olivarez, Mayvi Beristain-Guevara, César Ignacio Pascual-Pineda, Luz Alicia Jiménez Fernández, Maribel |
| spellingShingle |
Juárez-Trujillo, Naida Tapia-Hernández, Fredy Erubiel Alvarado-Olivarez, Mayvi Beristain-Guevara, César Ignacio Pascual-Pineda, Luz Alicia Jiménez Fernández, Maribel Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth |
| author_facet |
Juárez-Trujillo, Naida Tapia-Hernández, Fredy Erubiel Alvarado-Olivarez, Mayvi Beristain-Guevara, César Ignacio Pascual-Pineda, Luz Alicia Jiménez Fernández, Maribel |
| author_sort |
Juárez-Trujillo, Naida |
| title |
Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth |
| title_short |
Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth |
| title_full |
Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth |
| title_fullStr |
Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth |
| title_full_unstemmed |
Estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de Randia monantha Benth |
| title_sort |
estudio de actividad antibacteriana y toxicidad aguda de extracto acuoso estandarizado de fruto de randia monantha benth |
| description |
The fruit of Randia monantha is traditionally and empirically used in the preparation of a beverage as antivenom and for the treatment of various diseases, but to date there is little scientific evidence regarding its antimicrobiological properties and toxicity. The objective of this study was to evaluar the effect of the administration of the aqueous extract of the Randia monantha pulp on acute toxicity in male Wistar rats and evaluate antimicrobial activity at different concentrations against pathogenic bacteria. The results of acute oral toxicity revealed no deaths in doses up to 5000 mg / kg body weight. The experimental animals showed no significant changes in the weight and behavior parameters evaluated with respect to the control treatment. Rats did not show significant changes in the hematological parameters, but dosis of 5000 mg/kg body weight rats exhibited the appearance of yellow spots on kidney. The aqueous extract did not show antimicrobial activity against test pathogenic bacteria. These results suggest that the aqueous extract of the Randia monantha fruit can be used with some degree of safety by oral administration but should not be taken in high doses. |
| publisher |
Universidad de Sonora |
| publishDate |
2022 |
| url |
https://biotecnia.unison.mx/index.php/biotecnia/article/view/1516 |
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