Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl.
Nowadays the bioactive compounds from plants represent a great potential for discovering a novel drug that could act in cancer treatment. It has been reported that different species of Pine and oak possess cytotoxic activities against various cancer cell lines. In the present study, we evaluated the...
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| Główni autorzy: | , , , |
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| Format: | Online |
| Język: | eng |
| Wydane: |
Universidad de Sonora
2022
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| Dostęp online: | https://biotecnia.unison.mx/index.php/biotecnia/article/view/1520 |
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| Streszczenie: | Nowadays the bioactive compounds from plants represent a great potential for discovering a novel drug that could act in cancer treatment. It has been reported that different species of Pine and oak possess cytotoxic activities against various cancer cell lines. In the present study, we evaluated the phenolic profile and cytotoxic activities of crude and organic extracts from P. durangensis and Q. sideroxyla bark. Some compounds such as taxifolin and procyanidin dimers, were identified in extracts of both species by ESI-MS. The cytotoxic activity was performed on MDA-MB-231(breast cancer), HeLa (cervix cancer), MCF-10A (breast non-tumorous cell) and HSF-1184 (human skin fibroblast cells) by MTT assay. All extracts showed a dose-dependent cytotoxic effect against cancer cell lines and small or no activity against non-tumorous. The results provide important information about cytotoxic activity of bark extracts from P. durangensis and Q. sideroxyla. |
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