Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl.
Nowadays the bioactive compounds from plants represent a great potential for discovering a novel drug that could act in cancer treatment. It has been reported that different species of Pine and oak possess cytotoxic activities against various cancer cell lines. In the present study, we evaluated the...
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| स्वरूप: | Online |
| भाषा: | eng |
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Universidad de Sonora
2022
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| ऑनलाइन पहुंच: | https://biotecnia.unison.mx/index.php/biotecnia/article/view/1520 |
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biotecnia-article-15202022-05-31T17:40:22Z Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. In vitro cytotoxic activity of bark extracts from Pinus durangensis Martinez and Quercus sideroxyla Bonpl. Soto-García, Marcela Rosales-Castro, Martha García-Sánchez, José Rubén Rivas Arreola, María José extractos de corteza citotoxicidad perfil fenólico bark extracts cytotoxicity phenolic profile Nowadays the bioactive compounds from plants represent a great potential for discovering a novel drug that could act in cancer treatment. It has been reported that different species of Pine and oak possess cytotoxic activities against various cancer cell lines. In the present study, we evaluated the phenolic profile and cytotoxic activities of crude and organic extracts from P. durangensis and Q. sideroxyla bark. Some compounds such as taxifolin and procyanidin dimers, were identified in extracts of both species by ESI-MS. The cytotoxic activity was performed on MDA-MB-231(breast cancer), HeLa (cervix cancer), MCF-10A (breast non-tumorous cell) and HSF-1184 (human skin fibroblast cells) by MTT assay. All extracts showed a dose-dependent cytotoxic effect against cancer cell lines and small or no activity against non-tumorous. The results provide important information about cytotoxic activity of bark extracts from P. durangensis and Q. sideroxyla. En la actualidad, los compuestos bioactivos de las plantas representan un gran potencial para descubrir un fármaco novedoso que pueda actuar en el tratamiento del cáncer. Se ha informado que diferentes especies de pino y roble poseen actividades citotóxicas contra varias líneas celulares cancerosas. En el presente estudio, se evaluo el perfil fenólico y las actividades citotóxicas de extractos crudos y orgánicos de la corteza de P. durangensis y Q. sideroxyla. Algunos compuestos, como los dímeros de taxifolina y procianidina, fueron identificados en extractos de ambas especies mediante ESI-MS. La actividad citotóxica se realizó en MDA-MB-231 (cáncer de mama), HeLa (cáncer de cuello uterino), MCF-10A (células no tumorales de mama) y HSF-1184 (células de fibroblastos de piel humana) mediante ensayo MTT. Todos los extractos mostraron un efecto citotóxico dependiente de la dosis contra las líneas celulares cancerosas y poca o ninguna actividad contra las no tumorales. Los resultados proporcionan información importante sobre la actividad citotóxica de extractos de corteza de P. durangensis y Q. sideroxyla. Universidad de Sonora 2022-02-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original peer-reviewed articles Artículos originales evaluados por pares application/pdf text/xml https://biotecnia.unison.mx/index.php/biotecnia/article/view/1520 10.18633/biotecnia.v24i1.1520 Biotecnia; Vol. 24 No. 1 (2022): Enero-Abril; 55-61 Biotecnia; Vol. 24 Núm. 1 (2022): Enero-Abril; 55-61 1665-1456 1665-1456 eng https://biotecnia.unison.mx/index.php/biotecnia/article/view/1520/632 https://biotecnia.unison.mx/index.php/biotecnia/article/view/1520/669 Derechos de autor 2022 https://creativecommons.org/licenses/by-nc-sa/4.0 |
| institution |
Biotecnia |
| collection |
OJS |
| language |
eng |
| format |
Online |
| author |
Soto-García, Marcela Rosales-Castro, Martha García-Sánchez, José Rubén Rivas Arreola, María José |
| spellingShingle |
Soto-García, Marcela Rosales-Castro, Martha García-Sánchez, José Rubén Rivas Arreola, María José Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. |
| author_facet |
Soto-García, Marcela Rosales-Castro, Martha García-Sánchez, José Rubén Rivas Arreola, María José |
| author_sort |
Soto-García, Marcela |
| title |
Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. |
| title_short |
Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. |
| title_full |
Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. |
| title_fullStr |
Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. |
| title_full_unstemmed |
Actividad citotóxica in vitro de los extractos de Pinus durangensis Martinez y Quercus sideroxyla Bonpl. |
| title_sort |
actividad citotóxica in vitro de los extractos de pinus durangensis martinez y quercus sideroxyla bonpl. |
| description |
Nowadays the bioactive compounds from plants represent a great potential for discovering a novel drug that could act in cancer treatment. It has been reported that different species of Pine and oak possess cytotoxic activities against various cancer cell lines. In the present study, we evaluated the phenolic profile and cytotoxic activities of crude and organic extracts from P. durangensis and Q. sideroxyla bark. Some compounds such as taxifolin and procyanidin dimers, were identified in extracts of both species by ESI-MS. The cytotoxic activity was performed on MDA-MB-231(breast cancer), HeLa (cervix cancer), MCF-10A (breast non-tumorous cell) and HSF-1184 (human skin fibroblast cells) by MTT assay. All extracts showed a dose-dependent cytotoxic effect against cancer cell lines and small or no activity against non-tumorous. The results provide important information about cytotoxic activity of bark extracts from P. durangensis and Q. sideroxyla. |
| publisher |
Universidad de Sonora |
| publishDate |
2022 |
| url |
https://biotecnia.unison.mx/index.php/biotecnia/article/view/1520 |
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