Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico

Many reports state that different structures of M. grandiflora contain bioactive components. Nonetheless, phytochemical studies reported that the extracted essential oils are chemically different and remarkably variable in their qualitative and quantitative compositions. Further studies Mexican M. g...

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Autores principales:	Rivas-García, Tomás, Alejandre-Rosas, Jorge Alberto, Ramos-Ligonio, Ángel, Castillo-Morales, Marisol, Reyes-Pérez, Juan José, Esquivel-Valenzuela, Berenice
Formato:	Online
Lenguaje:	eng
Publicado:	Universidad de Sonora 2022
Acceso en línea:	https://biotecnia.unison.mx/index.php/biotecnia/article/view/1680
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id	biotecnia-article-1680
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institution	Biotecnia
collection	OJS
language	eng
format	Online
author	Rivas-García, Tomás Alejandre-Rosas, Jorge Alberto Ramos-Ligonio, Ángel Castillo-Morales, Marisol Reyes-Pérez, Juan José Esquivel-Valenzuela, Berenice
spellingShingle	Rivas-García, Tomás Alejandre-Rosas, Jorge Alberto Ramos-Ligonio, Ángel Castillo-Morales, Marisol Reyes-Pérez, Juan José Esquivel-Valenzuela, Berenice Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico
author_facet	Rivas-García, Tomás Alejandre-Rosas, Jorge Alberto Ramos-Ligonio, Ángel Castillo-Morales, Marisol Reyes-Pérez, Juan José Esquivel-Valenzuela, Berenice
author_sort	Rivas-García, Tomás
title	Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico
title_short	Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico
title_full	Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico
title_fullStr	Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico
title_full_unstemmed	Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico
title_sort	chemical composition, antioxidant activity and cytotoxicity of flower extracts from magnolia grandiflora l. found in southeast mexico
description	Many reports state that different structures of M. grandiflora contain bioactive components. Nonetheless, phytochemical studies reported that the extracted essential oils are chemically different and remarkably variable in their qualitative and quantitative compositions. Further studies Mexican M. grandiflora needs to be done. Thus, the research aimed to characterize a) the chemical composition, b) the antioxidant activity and c) cytotoxicity effect of two M. grandiflora flower extracts. The chemical composition was evaluated by preliminary phytochemical test followed by thin layer chromatography, UV-Vis and FTIR spectrophotometer analysis. The antioxidant activity of the flower extracts was measured by the free radical-scavenging activity (ABTS) and the stable radical of 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method and the cytotoxicity by an Artemia salina bioassay. Water and ethyl flower extracts showed the presence of organic chromophores such as flavonoids. Both extracts (ethyl and water) demonstrated antioxidant activity by both ABTS (459.6±8.5 µmol TE g-1 and 274.2±5.7 µmol TE g-1 respectively) and DPPH (3210.4 ± 2.5 µmol TE g-1 and 219.7 ± 0.9 µmol TE g-1 respectively) methologies; and non-cytotoxic activity (LC50 , µg mL-1) (1,285 ± 14 and 1,116 ± 15 respectively). The water and ethyl extracts of M. grandiflora flowers found in southeast Mexico are a promissory source of chemical compounds with attributed biological activity according to the presented results.
publisher	Universidad de Sonora
publishDate	2022
url	https://biotecnia.unison.mx/index.php/biotecnia/article/view/1680
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spelling	biotecnia-article-16802023-05-10T21:14:27Z Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico Composición química, actividad antioxidante y citotoxicidad de extractos de flores de Magnolia grandiflora L. encontradas en el sureste de México Rivas-García, Tomás Alejandre-Rosas, Jorge Alberto Ramos-Ligonio, Ángel Castillo-Morales, Marisol Reyes-Pérez, Juan José Esquivel-Valenzuela, Berenice Bioactive compounds Biological activity Medicinal plants Actividad biológica Compuestos bioactivos Plantas medicinales Many reports state that different structures of M. grandiflora contain bioactive components. Nonetheless, phytochemical studies reported that the extracted essential oils are chemically different and remarkably variable in their qualitative and quantitative compositions. Further studies Mexican M. grandiflora needs to be done. Thus, the research aimed to characterize a) the chemical composition, b) the antioxidant activity and c) cytotoxicity effect of two M. grandiflora flower extracts. The chemical composition was evaluated by preliminary phytochemical test followed by thin layer chromatography, UV-Vis and FTIR spectrophotometer analysis. The antioxidant activity of the flower extracts was measured by the free radical-scavenging activity (ABTS) and the stable radical of 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method and the cytotoxicity by an Artemia salina bioassay. Water and ethyl flower extracts showed the presence of organic chromophores such as flavonoids. Both extracts (ethyl and water) demonstrated antioxidant activity by both ABTS (459.6±8.5 µmol TE g-1 and 274.2±5.7 µmol TE g-1 respectively) and DPPH (3210.4 ± 2.5 µmol TE g-1 and 219.7 ± 0.9 µmol TE g-1 respectively) methologies; and non-cytotoxic activity (LC50 , µg mL-1) (1,285 ± 14 and 1,116 ± 15 respectively). The water and ethyl extracts of M. grandiflora flowers found in southeast Mexico are a promissory source of chemical compounds with attributed biological activity according to the presented results. Muchos estudios afirman que diferentes estructuras de M. grandiflora contienen componentes bioactivos. No obstante, los estudios fitoquímicos indican que los aceites esenciales extraídos son químicamente diferentes y notablemente variables en sus composiciones cualitativas y cuantitativas. Es necesario realizar más estudios sobre M. grandiflora cultivada en México. Por ello, el objetivo de esta investigación fue caracterizar a) la composición química, b) la actividad antioxidante y c) el efecto citotóxico de dos extractos de flores de M. grandiflora. La composición química se evaluó mediante una prueba fitoquímica preliminar seguida de cromatografía en capa fina y análisis espectrofotómetro mediante UV-Vis y FTIR. La actividad antioxidante de los extractos de flores se midió por el método de la actividad reductora de radicales libres (ABTS) y el método de radicales estables de 2,2-difenil-1-picril-hidrazilo (DPPH) y la citotoxicidad por un bioensayo de Artemia salina. Los extractos acuoso y etílico de flores mostraron la presencia de cromóforos orgánicos como los flavonoides. Ambos extractos (etilo y agua) demostraron actividad antioxidante tanto por ABTS (459,6 ± 8,5 µmol TE g-1 y 274,2 ± 5,7 µmol TE g-1 respectivamente) como por DPPH (3210,4 ± 2,5 µmol TE g-1 y 219,7 ± 0,9 µmol TE g-1 respectivamente) metodologías; y actividad no citotóxica (CL50, µg mL-1) (1,285±14 y 1,116±15 respectivamente). Los extractos acuosos y etílicos de las flores de M. grandiflora encontradas en el sureste de México son una fuente promisoria de compuestos químicos con actividad biológica atribuida por los resultados presentados. Universidad de Sonora 2022-11-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original peer-reviewed articles Artículos originales evaluados por pares application/pdf text/xml https://biotecnia.unison.mx/index.php/biotecnia/article/view/1680 10.18633/biotecnia.v25i1.1680 Biotecnia; Vol. 25 No. 1 (2023): January - April; 5 - 13 Biotecnia; Vol. 25 Núm. 1 (2023): Enero - Abril; 5 - 13 1665-1456 1665-1456 eng https://biotecnia.unison.mx/index.php/biotecnia/article/view/1680/729 https://biotecnia.unison.mx/index.php/biotecnia/article/view/1680/821 Derechos de autor 2022 https://creativecommons.org/licenses/by-nc-sa/4.0

Chemical composition, antioxidant activity and cytotoxicity of flower extracts from Magnolia grandiflora L. found in southeast Mexico

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