Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice

Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice

Metabolic diseases, including obesity and type 2 diabetes mellitus, represent a serious health and death problem in Mexico. The World Health Organization (WHO) and other associations such as the International Diabetes Federation (IDF) and the National Cholesterol Education Program-Adult Treatment Pa...

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Autores principales: Sollano-Mendieta, Xóchitl Cruz, Escalona-Cardoso, Gerardo Norberto, Cano-Europa, Edgar, Paniagua Castro, Norma
Formato: Online
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eng
Publicado: Universidad de Sonora 2022
Acceso en línea:https://biotecnia.unison.mx/index.php/biotecnia/article/view/1744
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spelling biotecnia-article-17442023-05-10T21:14:27Z Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice Propuesta de un modelo de síndrome metabólico en ratones CD1 inducido con una dieta hipercalórica: Modelo murino de síndrome metabólico Sollano-Mendieta, Xóchitl Cruz Escalona-Cardoso, Gerardo Norberto Cano-Europa, Edgar Paniagua Castro, Norma Hypercaloric diet metabolic syndrome murine model obesity Dieta hipercalórica Síndrome metabóico Modelo murino Obesidad Metabolic diseases, including obesity and type 2 diabetes mellitus, represent a serious health and death problem in Mexico. The World Health Organization (WHO) and other associations such as the International Diabetes Federation (IDF) and the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) define the Metabolic Syndrome (MetS), as the set of metabolic alterations that lead to the development of obesity, hypertension, and diabetes mellitus. The objective of this study was to develop a model of MS in CD1 rodents using a hypercaloric diet and to determine the advantages and / or disadvantages compared to other murine models. Female and male CD1 mice were divided into 2 groups by gender, a control group, and another group with a hypercaloric diet for 10 weeks. The results obtained showed that the hypercaloric diet is efficient to develop the metabolic alterations present in MetS, better results were observed in male mice, which is why the use in this genus is suggested to avoid the hormonal changes present in adult females Las enfermedades metabólicas, incluyendo la obesidad y la diabetes mellitus tipo 2, representan un grave problema de salud y mortalidad, en México. La Organización Mundial de la Salud (OMS) y otras asociaciones como la Federación internacional de la Diabetes (IDF) y el Programa Nacional de Educación para el Colesterol-Panel de Tratamiento para el Adulto III (NCEP-ATP III) definen el Síndrome Metabólico (SM), como la agrupación de alteraciones metabólicas que conllevan al desarrollo de obesidad, hipertensión y diabetes mellitus. El objetivo de este estudio fue desarrollar un modelo de SM en roedores CD1 utilizando una dieta hipercalórica y determinar las ventajas y/o desventajas comparado con otros modelos murinos. Se utilizaron ratones CD1 hembras y machos se dividieron en 2 grupos por género, un grupo control y otro grupo con dieta hipercalórica durante 10 semanas. Los resultados obtenidos mostraron que la dieta hipercalórica es eficiente para desarrollar las alteraciones metabólicas presentes en el SM, se observaron mejores resultados en los ratones macho, por lo que se sugiere la utilización en este género para evitar los cambios hormonales presentes en las hembras adultas Universidad de Sonora 2022-12-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Original peer-reviewed articles Artículos originales evaluados por pares application/pdf text/xml https://biotecnia.unison.mx/index.php/biotecnia/article/view/1744 10.18633/biotecnia.v25i1.1744 Biotecnia; Vol. 25 No. 1 (2023): January - April; 126 - 132 Biotecnia; Vol. 25 Núm. 1 (2023): Enero - Abril; 126 - 132 1665-1456 1665-1456 spa eng https://biotecnia.unison.mx/index.php/biotecnia/article/view/1744/739 https://biotecnia.unison.mx/index.php/biotecnia/article/view/1744/835 Derechos de autor 2022 https://creativecommons.org/licenses/by-nc-sa/4.0
institution Biotecnia
collection OJS
language spa
eng
format Online
author Sollano-Mendieta, Xóchitl Cruz
Escalona-Cardoso, Gerardo Norberto
Cano-Europa, Edgar
Paniagua Castro, Norma
spellingShingle Sollano-Mendieta, Xóchitl Cruz
Escalona-Cardoso, Gerardo Norberto
Cano-Europa, Edgar
Paniagua Castro, Norma
Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice
author_facet Sollano-Mendieta, Xóchitl Cruz
Escalona-Cardoso, Gerardo Norberto
Cano-Europa, Edgar
Paniagua Castro, Norma
author_sort Sollano-Mendieta, Xóchitl Cruz
title Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice
title_short Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice
title_full Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice
title_fullStr Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice
title_full_unstemmed Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice
title_sort proposal for a metabolic syndrome model in cd1 mice induced with a hypercaloric diet: metabolic syndrome model in cd1 mice
description Metabolic diseases, including obesity and type 2 diabetes mellitus, represent a serious health and death problem in Mexico. The World Health Organization (WHO) and other associations such as the International Diabetes Federation (IDF) and the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) define the Metabolic Syndrome (MetS), as the set of metabolic alterations that lead to the development of obesity, hypertension, and diabetes mellitus. The objective of this study was to develop a model of MS in CD1 rodents using a hypercaloric diet and to determine the advantages and / or disadvantages compared to other murine models. Female and male CD1 mice were divided into 2 groups by gender, a control group, and another group with a hypercaloric diet for 10 weeks. The results obtained showed that the hypercaloric diet is efficient to develop the metabolic alterations present in MetS, better results were observed in male mice, which is why the use in this genus is suggested to avoid the hormonal changes present in adult females
publisher Universidad de Sonora
publishDate 2022
url https://biotecnia.unison.mx/index.php/biotecnia/article/view/1744
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