Reprogramming of alternative splicing of genes associated with breast cancer

Alternative splicing is a process that modulates gene expression and contributes to protein diversity. However, alterations have been observed that harm alternative splicing and promote the development of oncogenic isoforms in breast cancer. Breast cancer is the most common neoplasm in women and the...

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Asıl Yazarlar:	Rossano Gutiérrez, Kate Ariadna, Martínez Montiel, Nancy, Anaya Ruiz, Maricruz, Gaspariano Cholula, Mayra Patricia, Martínez Contreras, Rebeca Débora
Materyal Türü:	Online
Dil:	spa
Baskı/Yayın Bilgisi:	Universida de Sonora 2021
Online Erişim:	https://epistemus.unison.mx/index.php/epistemus/article/view/186
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spelling	oai:http:--epistemus.unison.mx:article-1862023-06-14T01:04:22Z Reprogramming of alternative splicing of genes associated with breast cancer Reprogramación del splicing alternativo de genes asociados a cáncer de mama Rossano Gutiérrez, Kate Ariadna Martínez Montiel, Nancy Anaya Ruiz, Maricruz Gaspariano Cholula, Mayra Patricia Martínez Contreras, Rebeca Débora splicing cáncer mamario oligonucleótidos antisentido splicing breast cancer antisense oligonucleotides Alternative splicing is a process that modulates gene expression and contributes to protein diversity. However, alterations have been observed that harm alternative splicing and promote the development of oncogenic isoforms in breast cancer. Breast cancer is the most common neoplasm in women and the leading cause of death from cancer. This paper analyzes the expression of isoforms involved in tumor progression and the use of antisense oligonucleotides as a treatment for breast cancer. The information reveals that the deregulation of the BirC5 and KLF6 genes is involved in tumor progression and invasion, inhibition of cell death, and metastasis. In addition, antisense oligonucleotide therapies are reported, which re-establish alternative splicing of genes involved in spinal muscle atrophy, pancreatic cancer, colon cancer, and glioblastoma. El splicing alternativo es un proceso que modula la expresión génica y contribuye en la diversidad proteica. Sin embargo, se han observado que alteraciones en el splicing alternativo de algunos genes promueve el desarrollo de isoformas oncogénicas en cáncer de mama. Debido a que el cáncer de mama es la neoplasia más frecuente en mujeres y la primera causa de muerte por cáncer. El presente trabajo analiza la expresión de isoformas involucradas en la progresión tumoral y considera ideal el uso de oligonucleótidos antisentido como tratamiento contra cáncer de mama. La información revela que la desregulación de los genes BirC5 y KLF6 se asocia a la inhibición de la muerte celular y metástasis. Además, la existencia de terapias que utilizan oligonucleótidos antisentido es una realidad, tal es el caso del tratamiento utilizado en la atrofia muscular espinal, que ha brindado excelentes resultados a los pacientes que sufren de esta enfermedad. Universida de Sonora 2021-12-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion CienTecYSoc CienTecYSoc application/pdf text/xml https://epistemus.unison.mx/index.php/epistemus/article/view/186 10.36790/epistemus.v15i30.186 EPISTEMUS; Vol. 15 No. 30 (2021): Issue 30; 75-82 EPISTEMUS; Vol. 15 Núm. 30 (2021): Revista No. 30; 75-82 2007-8196 2007-4530 spa https://epistemus.unison.mx/index.php/epistemus/article/view/186/244 https://epistemus.unison.mx/index.php/epistemus/article/view/186/209 Derechos de autor 2021 EPISTEMUS https://creativecommons.org/licenses/by-nc-nd/4.0
institution	Epistemus
collection	OJS
language	spa
format	Online
author	Rossano Gutiérrez, Kate Ariadna Martínez Montiel, Nancy Anaya Ruiz, Maricruz Gaspariano Cholula, Mayra Patricia Martínez Contreras, Rebeca Débora
spellingShingle	Rossano Gutiérrez, Kate Ariadna Martínez Montiel, Nancy Anaya Ruiz, Maricruz Gaspariano Cholula, Mayra Patricia Martínez Contreras, Rebeca Débora Reprogramming of alternative splicing of genes associated with breast cancer
author_facet	Rossano Gutiérrez, Kate Ariadna Martínez Montiel, Nancy Anaya Ruiz, Maricruz Gaspariano Cholula, Mayra Patricia Martínez Contreras, Rebeca Débora
author_sort	Rossano Gutiérrez, Kate Ariadna
title	Reprogramming of alternative splicing of genes associated with breast cancer
title_short	Reprogramming of alternative splicing of genes associated with breast cancer
title_full	Reprogramming of alternative splicing of genes associated with breast cancer
title_fullStr	Reprogramming of alternative splicing of genes associated with breast cancer
title_full_unstemmed	Reprogramming of alternative splicing of genes associated with breast cancer
title_sort	reprogramming of alternative splicing of genes associated with breast cancer
description	Alternative splicing is a process that modulates gene expression and contributes to protein diversity. However, alterations have been observed that harm alternative splicing and promote the development of oncogenic isoforms in breast cancer. Breast cancer is the most common neoplasm in women and the leading cause of death from cancer. This paper analyzes the expression of isoforms involved in tumor progression and the use of antisense oligonucleotides as a treatment for breast cancer. The information reveals that the deregulation of the BirC5 and KLF6 genes is involved in tumor progression and invasion, inhibition of cell death, and metastasis. In addition, antisense oligonucleotide therapies are reported, which re-establish alternative splicing of genes involved in spinal muscle atrophy, pancreatic cancer, colon cancer, and glioblastoma.
publisher	Universida de Sonora
publishDate	2021
url	https://epistemus.unison.mx/index.php/epistemus/article/view/186
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Reprogramming of alternative splicing of genes associated with breast cancer

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