Proposal for a metabolic syndrome model in CD1 mice induced with a hypercaloric diet: Metabolic syndrome model in CD1 mice

Metabolic diseases, including obesity and type 2 diabetes mellitus, represent a serious health and death problem in Mexico. The World Health Organization (WHO) and other associations such as the International Diabetes Federation (IDF) and the National Cholesterol Education Program-Adult Treatment Pa...

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Autores principales: Sollano-Mendieta, Xóchitl Cruz, Escalona-Cardoso, Gerardo Norberto, Cano-Europa, Edgar, Paniagua Castro, Norma
格式: Online
語言:spa
eng
出版: Universidad de Sonora 2022
在線閱讀:https://biotecnia.unison.mx/index.php/biotecnia/article/view/1744
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總結:Metabolic diseases, including obesity and type 2 diabetes mellitus, represent a serious health and death problem in Mexico. The World Health Organization (WHO) and other associations such as the International Diabetes Federation (IDF) and the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) define the Metabolic Syndrome (MetS), as the set of metabolic alterations that lead to the development of obesity, hypertension, and diabetes mellitus. The objective of this study was to develop a model of MS in CD1 rodents using a hypercaloric diet and to determine the advantages and / or disadvantages compared to other murine models. Female and male CD1 mice were divided into 2 groups by gender, a control group, and another group with a hypercaloric diet for 10 weeks. The results obtained showed that the hypercaloric diet is efficient to develop the metabolic alterations present in MetS, better results were observed in male mice, which is why the use in this genus is suggested to avoid the hormonal changes present in adult females