NMDA Encephalitis: Case report and literature review
Autoimmune encephalitis characterized by the presence of IgG antibodies to the GluR1 subunit of Nmethyl-D-Aspartate receptor (NMDAr) mainly affects women over 18 years old and is commonly associated with an ovarian teratoma. It was previously described as a paraneoplastic disease; however, it has be...
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| Autores principales: | , , , |
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| Formato: | Online |
| Idioma: | spa |
| Publicado: |
REMUS - Revista Estudiantil de Medicina de la Universidad de Sonora
2020
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| Acceso en liña: | https://ojs-remus.unison.mx/index.php/remus_unison/article/view/22 |
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| Sumario: | Autoimmune encephalitis characterized by the presence of IgG antibodies to the GluR1 subunit of Nmethyl-D-Aspartate receptor (NMDAr) mainly affects women over 18 years old and is commonly associated with an ovarian teratoma. It was previously described as a paraneoplastic disease; however, it has been shown that it affects both genders and that the condition may be present without an underlying tumor. We present a case of a 20-year-old female who initially presented headaches, followed by behavioral changes. After that, she progressed to a catatonic state and central hypoventilation, requiring admission to intensive care. During her hospital stay, she presented autonomic dysfunction and dyskinesias. A serum diagnosis of anti-NMDAr encephalitis is made, starting immunosuppressive treatment with steroids, followed by rituximab. The patient had a remarkable improvement and complete recovery from the disease. |
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